I've read a book set in our world with witches, vampires, etc, all living in secret and some humans know of their existance and try to hunt them down. I can't remember the title but I think you should still go for the idea.
It may have been done once or twice, but it certainly isn't something that you see often. Give it a shot, see what happens. Even if it isn't original to begin with, often it will become more original in the details and the characters.
The robbed that smiles, steals something from the thief. ~William Shakespeare, Othello Boo. SPEW is watching.
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