Young Demetri Takari has a pretty smooth life until he is excepted into the city's alchemist guild at age 16. There he officially meets two people that will change his life, Shasta and Shiki Kuru. The Kuru twins, as they are often refered to as, are the two greatest enemies of Demetri's family because they are the heirs to the Kuru family, a family that has been a huge rival to the Takari family for many generations. As heir to his own family, Demetri must make the decision to either stick around with his friend Shasta or do as she wishes and abandon her. Though, Shasta and Shiki are no average 18 year olds for they are immortal. Gifted by eternal life, the two have different reactions towards themselves. While Shiki plans to do good with this gift, his sister Shasta only seeks more and more bloodshed. As a member of the dreaded elite who only live for the kill, she seeks an end to her life which she deems meaningless. While Shasta strives for bloodshed according to her plans, Demetri does everything he can to make his friend realize that her life is not meaningless. For everyone has their own special proof of life.